JMU21VT16No. Or at least, not even remotely well. This amp puts 230 mW into 32 ohm and exponentially less than that into 600 ohm. As a point of reference, I have an amp that puts 2000mW into 32 ohm, and 320 mW into 600 ohm. That *might* be enough to run those cans well. The problem is the DT 880 600 ohm have a spike in impedance. At roughly 70 hz, the impedance becomes 730 ohm, meaning that to fully power those cans, you need to be able to put 200mW (the maximum power handling for those headphones) into 730 ohm. That is a tall order.