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Can I run this with my Fiio E10k usb amp/dac or is that not powerful enough? I'm thinking about buying them but don't want to buy another stand alone amp. I have the grado sr225e but their impedance is nothing compared to 300 ohms. Thanks
It's probably not the best option. Fiio responded to someone in a forum thread saying, "The E10K may not have enough power to drive the HD650. So it is not recommended to collocate like that."
The E10k will be enough drive the 6XX/650 to roughly 111dB (sensitivity 103dB/Vrms, source output of 2.53Vrms). That should be good enough for most music, but may fall short when it comes to music with wide dynamic range, like classical or some types of jazz. I've trialled my friend's 650 with my e10k and it was loud enough even on low gain, and she couldn't hear any obvious distortion or clipping compared to her usual set up.
So basically, at more realistic listening levels where you aren't constantly causing yourself permanent hearing loss, it should be fine but if you enjoy cranking it up to rock concert levels of loudness every now and then I'd try a different amp.
I've personally used them with my phone without problems (Note 8 with Exynos CPU, its DAC can output 0.94 Vrms, YMMV if you're planning using them with your smartphone), it gets loud enough that I use them with the volume slider about 2/3 of the way up, but I have little to no room if I want to equalize them. On my desktop I use them plugged directly into my motherboard and I really rarely go over 40% volume (it's usually about 25-30%), reaching 60% if I want to blast my ears off, so I don't even feel the need of an amp. Then again, if you are listening to music which has a ton of dynamic range and you like equalizing headphones you might need a more powerful amplifier, or you might not, I can only tell you about my personal experience; if, like me, you basically only listen to contemporary music and still have pretty good hearing you are good with what you already have