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The MSI stealth laptops are MUCH easier to transport and fit maybe a little better in a work environment. I change locations roughly 8 times a year (for extended periods of time), so the larger laptop was a good trade-off between increased mobility vs better thermals+slightly better/more reliable performance. There are a LOT of good options now with the gtx10 series being so powerful. Hope my perspective helps you or anyone else looking into this tricky market! It's not easy to decide on these machines!!!
Some people dont travel a lot, so a desktop replacement benefit them. At this area, i would consider laptops with water cooling, but they are super expensive atm.
Some people now have the option to carry a slimmer versioon of a desktop. Pascal allows for gpu to almost reach the counter part (desktop). Also, you can use external gpu on some of the slim models. Gpu used to be the biggest issue on a laptop as cpu hardly improved in the lastest generation.