The caveat to this is that some devices really sound like a** with reduced gain (I experienced this with Liquid Carbon, not the Drop Liquid Carbon X mind. I also found Schiit Magni 3 to sound better on high gain). This has to do with how reduction in volume is achieved; some amps run feedback loops to reduce gain, which sometimes makes the sound bad.
That being said, clipping is really awful.
Just try high gain/low gain and see if you hear a difference. If not, great!