Memory foam is your friend here, just as it was for the first astronauts is was designed to provide support for. The Sennheiser HD700 seem to be the benchmark for comfort, I can attest to this. A well designed support system, such as in the Elex, makes even a weightier set feel at home. The Senn 600’s can be easily, gently opened up. Those do feel more comfortable with new Dekoni memory foam pads, esp. for additional cartilage clearance. Over-the-ear full size cups are the way to go for long term comfort, avoid “on-ear”.