It really depends on what you are doing with your photography bag.
If you are a pro or semi pro who just needs to transport your gear to the job, I can't find fault with the various Lowepro, Manfrotto and Pelican solutions.
However, if you are doing walk around with a bag on your back photography. Such as street photography, or just being a plain old tourist, I think such brands are a bad idea.
Thieves aren't stupid. They know to look for bags that are photo-equipment specific.
For this reason I stick to non-photography bags. Or bags made by companies that also make regular bags for regular Janes and Joes. Such as Chrome Industries, Manhattan Portage etc.
Currently own a Manhattan Portage Focus and a Pelican uh, forgot the name bubt it's a backpack with a rigid laptop section. I use the Focus as my daily driver. The laptop and camera sections are removable and the bag can be cinched down very small. Or for gigs or weekends I can expand it to carry camera, lenses, some clothes, laptop and misc gear.
The Pelican is my legit gig bag. It can fit everything and it's got super solid straps and lumbar pads.