TpsytrvyIt does to me, particularly if the ink isn't colorfast. Ink should be stored in a dark place out of the sun, and no box means it's possible these have been hanging out on a store-shelf somewhere and the ink's color properties may be affected. These are dye-based, and so over time they may fade in bright light. Additionally, some ink manufacturers list a date-of-manufacture on the box (Montblanc used to include a 'best before' tag on their boxes).
I'm a big fan of boxed inks.