I believe you can use this set with any keyboard that utilizes mx switches, and regarding the different sets, yes you will need to buy several sets to get complete coverage depending on how big your board is. In my case, I have a 60%, so I needed the alphas and the modifier set to get complete coverage. Plus the alt color set for the pop. With a bigger keyboard, you might need the numpad and/or mod plus set as well. Hope this helped.