To everyone that's talking about the bottle opener, I think they're maybe on the wrong track. Frankly I assumed the original post about the huge hotspot on the palm was a reference to the end of the clip, not the bottle opener.
It's hard to say for sure whether or not it'd rub, but when you look at how far down the angle is canted on that bottle opener it looks like it's out of the palm's way. The hump of the spine will be what's buried in the meat of your palm, and I think that bottle opener's going to be pointing away from it unless you're holding it with a very odd grip.
In any case I'm not super worried about it -- because this is the sort of knife I'd put in my pocket if I intended to pop a couple adult sodas, not if I had a few thousand boxes to break down.
For the person who's going 'WTF, maybe you folks ain't been watching the news but there's no way I have $125 for this, please do a version I can afford:' there's an Ochs knife with a bottle opener that CRKT's selling for under $40 called the Bev Edge, that is based on the Ochs Lagoon, not the Otter. That might be more your speed -- but lol be warned, some people harbor strong opinions as to how different these two knives are, and you might have some extra conversation along with your knife.
Me? I'm thinking of picking one of these up.