terman2I use it at work on a Mac and I use Karabiner Elements to map the cmd/option/control keys the way I want them. I also use it to set up a one key print screen. The media buttons work out of the box though, which would have been a headache otherwise.
claastrange. my setup is that i have the keyboard and mouse plugged into a 4 port which is in turn plugged into a usb to usb-c dongle that is then plugged into the mac. what is your setup?