I'm a W5000 and an AD2000 owner. I'd say instrumentals--the W5000 is king. For vocals, the AD2000 can't be beat (not even by its successor, the AD2000X). Audio-Technica has a house sound, but there's a reason they're so coveted.
If you're a M50x user, this is a completely different animal being offered here, so I wouldn't let impressions muddy what these will be like. :) Y'all got my 10/10 recommendation!